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Structure paper

TitleStabilizer-Guided Inhibition of Protein-Protein Interactions.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 54, Page 15720-15724, Year 2015
Publish dateFeb 10, 2015 (structure data deposition date)
AuthorsMilroy, L.G. / Bartel, M. / Henen, M.A. / Leysen, S. / Adriaans, J.M. / Brunsveld, L. / Landrieu, I. / Ottmann, C.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:26537010
MethodsX-ray diffraction
Resolution1.4 - 1.8 Å
Structure data

PDB-4y32:
Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4y5i:
Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-5hf3:
Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-49F:
(2S)-2-(2-methoxyethyl)pyrrolidine

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN / Peptide-hybrid / Inhibitor / Protein-protein interaction / Peptide binding protein / Adapter protein / 14-3-3 / 14-3-3 sigma / tau

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