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Structure paper

TitleFOX-4 cephamycinase: an analysis of structure and function.
Journal, issue, pagesAntimicrob. Agents Chemother., Year 2015
Publish dateJul 9, 2015 (structure data deposition date)
AuthorsLefurgy, S.T. / Malashkevich, V.N. / Aguilan, J.T. / Nieves, E. / Mundorff, E.C. / Biju, B. / Noel, M.A. / Toro, R. / Baiwir, D. / Papp-Wallace, K.M. ...Lefurgy, S.T. / Malashkevich, V.N. / Aguilan, J.T. / Nieves, E. / Mundorff, E.C. / Biju, B. / Noel, M.A. / Toro, R. / Baiwir, D. / Papp-Wallace, K.M. / Almo, S.C. / Frere, J.M. / Bou, G. / Bonomo, R.A.
External linksAntimicrob. Agents Chemother. / PubMed:26525784
MethodsX-ray diffraction
Resolution1.21 - 1.634 Å
Structure data

PDB-5cgs:
CRYSTAL STRUCTURE OF Fox-4 cephamycinase
Method: X-RAY DIFFRACTION / Resolution: 1.634 Å

PDB-5cgw:
CRYSTAL STRUCTURE OF Fox-4 cephamycinase mutant Y150F
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-5cgx:
CRYSTAL STRUCTURE OF Fox-4 cephamycinase mutant Y150F complexed with cefoxitin
Method: X-RAY DIFFRACTION / Resolution: 1.21 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-1S7:
(2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid / antibiotic*YM

ChemComp-NA:
Unknown entry

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / beta-lactamase

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