タイトル | Uncovering the Mechanism of Aggregation of Human Transthyretin. |
---|
ジャーナル・号・ページ | J. Biol. Chem., Vol. 290, Page 28932-28943, Year 2015 |
---|
掲載日 | 2014年5月27日 (構造データの登録日) |
---|
著者 | Saelices, L. / Johnson, L.M. / Liang, W.Y. / Sawaya, M.R. / Cascio, D. / Ruchala, P. / Whitelegge, J. / Jiang, L. / Riek, R. / Eisenberg, D.S. |
---|
リンク | J. Biol. Chem. / PubMed:26459562 |
---|
手法 | X線回折 |
---|
解像度 | 1.35 - 1.85 Å |
---|
構造データ | PDB-4tkw: Crystal Structure of Human Transthyretin Leu55Pro Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4tl4: Crystal Structure of Human Transthyretin Val30Met Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4tl5: Crystal Structure of Human Transthyretin Ser85Pro Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-4tlk: Crystal Structure of Human Transthyretin Ser85Pro/Glu92Pro Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-4tls: Crystal Structure of Human Transthyretin Glu92Pro Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-4tlt: Crystal structure of human transthyretin 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4tm9: Crystal Structure of Human Transthyretin Thr119Trp Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4tne: Crystal Structure of Human Transthyretin Thr119Tyr Mutant 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4xfn: Structure of an Amyloid forming peptide AEVVFT from Human Transthyretin 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4xfo: Structure of an amyloid-forming segment TAVVTN from human Transthyretin 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å |
---|
化合物 | |
---|
由来 | homo sapiens (ヒト)- synthetic construct (人工物)
|
---|
キーワード | TRANSPORT PROTEIN / human transthyretin / amyloid / transthyretin / mutant / PROTEIN FIBRIL / fibril |
---|