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Structure paper

TitleCrystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page E5391-E5400, Year 2015
Publish dateAug 25, 2015 (structure data deposition date)
AuthorsVasilyev, N. / Polonskaia, A. / Darnell, J.C. / Darnell, R.B. / Patel, D.J. / Serganov, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:26374839
MethodsX-ray diffraction
Resolution2.7973 - 3.1003 Å
Structure data

PDB-5de5:
Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA.
Method: X-RAY DIFFRACTION / Resolution: 3.0011 Å

PDB-5de8:
Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA, iridium hexammine bound form.
Method: X-RAY DIFFRACTION / Resolution: 3.1003 Å

PDB-5dea:
Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA, cesium bound form.
Method: X-RAY DIFFRACTION / Resolution: 2.7973 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-IRI:
IRIDIUM HEXAMMINE ION

ChemComp-CS:
Unknown entry

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsRNA binding protein/RNA / Fragile X syndrome / RNA structure / RGG box / FMRP / G-quadruplex / RNA binding protein-RNA complex

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