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-Structure paper
Title | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 7707-7718, Year 2015 |
Publish date | Nov 12, 2014 (structure data deposition date) |
![]() | Watson, G.M. / Gunzburg, M.J. / Ambaye, N.D. / Lucas, W.A. / Traore, D.A. / Kulkarni, K. / Cergol, K.M. / Payne, R.J. / Panjikar, S. / Pero, S.C. ...Watson, G.M. / Gunzburg, M.J. / Ambaye, N.D. / Lucas, W.A. / Traore, D.A. / Kulkarni, K. / Cergol, K.M. / Payne, R.J. / Panjikar, S. / Pero, S.C. / Perlmutter, P. / Wilce, M.C. / Wilce, J.A. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 2.55 Å |
Structure data | ![]() PDB-4wwq: ![]() PDB-4x6s: |
Chemicals | ![]() ChemComp-MLA: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / src Homology Domain / phosphotyrosine binding pocket / Signaling Protein/Inhibitor / inhibitor / Signaling Protein-Inhibitor complex |