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Structure paper

TitleOrally bioavailable Syk inhibitors with activity in a rat PK/PD model.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 25, Page 4642-4647, Year 2015
Publish dateJul 29, 2015 (structure data deposition date)
AuthorsThoma, G. / Veenstra, S. / Strang, R. / Blanz, J. / Vangrevelinghe, E. / Berghausen, J. / Lee, C.C. / Zerwes, H.G.
External linksBioorg. Med. Chem. Lett. / PubMed:26320624
MethodsX-ray diffraction
Resolution1.7 - 1.9 Å
Structure data

PDB-5cxh:
SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5cxz:
SYK catalytic domain complexed with naphthyridine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5cy3:
SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

ChemComp-55M:
(4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-55U:
N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine

ChemComp-55Y:
(5R)-5-[(1R)-1-{[6-(1-methyl-1H-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase inhibitor / Transferase-Transferase inhibitor complex

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