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TitleAltiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Journal, issue, pagesMol. Cancer Ther., Vol. 14, Page 2023-2034, Year 2015
Publish dateAug 27, 2015 (structure data deposition date)
AuthorsSmith, B.D. / Kaufman, M.D. / Leary, C.B. / Turner, B.A. / Wise, S.C. / Ahn, Y.M. / Booth, R.J. / Caldwell, T.M. / Ensinger, C.L. / Hood, M.M. ...Smith, B.D. / Kaufman, M.D. / Leary, C.B. / Turner, B.A. / Wise, S.C. / Ahn, Y.M. / Booth, R.J. / Caldwell, T.M. / Ensinger, C.L. / Hood, M.M. / Lu, W.P. / Patt, T.W. / Patt, W.C. / Rutkoski, T.J. / Samarakoon, T. / Telikepalli, H. / Vogeti, L. / Vogeti, S. / Yates, K.M. / Chun, L. / Stewart, L.J. / Clare, M. / Flynn, D.L.
External linksMol. Cancer Ther. / PubMed:26285778
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5dg5:
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-5B4:
N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / TYROSINE KINASE DOMAIN / HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET / C-MET / ALTIRATINIB ANALOG / DP-4157 / TRANSFERASE-TRANSFERASE INHIBITOR complex

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