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TitleThe soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.
Journal, issue, pagesActa Crystallogr. ,Sect. F, Vol. 71, Page 986-992, Year 2015
Publish dateMar 18, 2015 (structure data deposition date)
AuthorsDiPisa, F. / Pozzi, C. / Benvenuti, M. / Andreini, M. / Marconi, G. / Mangani, S.
External linksActa Crystallogr. ,Sect. F / PubMed:26249687
MethodsX-ray diffraction
Resolution1.95 - 2.1 Å
Structure data

PDB-4yu9:
Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4ywy:
Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase in complex with inhibitor PBD-150
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-PBD:
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Alzheimer Disease / Drug Target / Cyclotransferase Soluble Variant / PBD-150 inhibitor

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