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TitleInteractions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts.
Journal, issue, pagesJ. Inorg. Biochem., Vol. 153, Page 136-142, Year 2015
Publish dateJan 4, 2015 (structure data deposition date)
AuthorsMessori, L. / Marzo, T. / Merlino, A.
External linksJ. Inorg. Biochem. / PubMed:26239545
MethodsX-ray diffraction
Resolution2.09 - 2.27 Å
Structure data

PDB-4s0q:
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and carboplatin
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-4s18:
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-QPT:
carboplatin / medication, chemotherapy*YM

ChemComp-HOH:
WATER

ChemComp-1PT:
CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II) / medication, antineoplastic*YM

Source
  • bos taurus (cattle)
KeywordsHYDROLASE/RNA / ribonuclease / RNA cleavage / HYDROLASE-RNA complex / HYDROLASE / ribonuclease fold / cleavage of RNA / RNA / bovine pancreas

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