タイトル | The active site of O-GlcNAc transferase imposes constraints on substrate sequence. |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Vol. 22, Page 744-750, Year 2015 |
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掲載日 | 2015年1月6日 (構造データの登録日) |
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著者 | Pathak, S. / Alonso, J. / Schimpl, M. / Rafie, K. / Blair, D.E. / Borodkin, V.S. / Schuttelkopf, A.W. / Albarbarawi, O. / van Aalten, D.M. |
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リンク | Nat. Struct. Mol. Biol. / PubMed:26237509 |
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手法 | X線回折 |
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解像度 | 2.05 - 3.2 Å |
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構造データ | PDB-4xi9: Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2) 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-4xif: Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (keratin-7) 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-5bnw: The active site of O-GlcNAc transferase imposes constraints on substrate sequence 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5c1d: Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RB2L) 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å |
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化合物 | ChemComp-12V: (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate / ウリジン5′-二りん酸P2-[3α-(アセチルアミノ)-4β,5α-ジヒドロキシ-6β-(ヒドロ(以下略)
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / O-GlcNAc transferase inverting GT-B substrate complex / o-glcnac transferase / glycosyl transferase |
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