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Structure paper

TitleDifferent binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor alpha / gamma.
Journal, issue, pagesJ. Struct. Biol., Vol. 191, Page 332-340, Year 2015
Publish dateDec 5, 2013 (structure data deposition date)
Authorsdos Santos, J.C. / Bernardes, A. / Giampietro, L. / Ammazzalorso, A. / De Filippis, B. / Amoroso, R. / Polikarpov, I.
External linksJ. Struct. Biol. / PubMed:26185032
MethodsX-ray diffraction
Resolution1.77 - 2.302 Å
Structure data

PDB-4ci4:
Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

PDB-4ci5:
Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor gamma agonist
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-Y1N:
2-methyl-2-[4-[2-[4-[(E)-phenyldiazenyl]phenoxy]ethyl]phenoxy]propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / DUAL AGONIST / PPAR / NUCLEAR RECEPTOR / GL479 / NUCLEAR PROTEIN

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