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TitleCharacterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
Journal, issue, pagesPlos Pathog., Vol. 11, Page e1005035-e1005035, Year 2015
Publish dateMay 21, 2015 (structure data deposition date)
AuthorsGilman, M.S. / Moin, S.M. / Mas, V. / Chen, M. / Patel, N.K. / Kramer, K. / Zhu, Q. / Kabeche, S.C. / Kumar, A. / Palomo, C. ...Gilman, M.S. / Moin, S.M. / Mas, V. / Chen, M. / Patel, N.K. / Kramer, K. / Zhu, Q. / Kabeche, S.C. / Kumar, A. / Palomo, C. / Beaumont, T. / Baxa, U. / Ulbrandt, N.D. / Melero, J.A. / Graham, B.S. / McLellan, J.S.
External linksPlos Pathog. / PubMed:26161532
MethodsX-ray diffraction
Resolution2 - 5.5 Å
Structure data

PDB-4zyk:
Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4zyp:
Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 5.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • human respiratory syncytial virus a (strain a2)
  • enterobacteria phage t4 (virus)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Ig domain / Fab / fusion / respiratory syncytial virus / prefusion

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