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TitleDiscovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 25, Page 3621-3625, Year 2015
Publish dateMay 21, 2015 (structure data deposition date)
AuthorsGessier, F. / Kallen, J. / Jacoby, E. / Chene, P. / Stachyra-Valat, T. / Ruetz, S. / Jeay, S. / Holzer, P. / Masuya, K. / Furet, P.
External linksBioorg. Med. Chem. Lett. / PubMed:26141769
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-4zyc:
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-4SS:
(S)-2-(2-((2H-tetrazol-5-yl)methoxy)-4-methylphenyl)-1-(4-chlorophenyl)-6,7-diethoxy-1,2-dihydroisoquinolin-3(4H)-one

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / PPI WITH P53 / INHIBITOR COMPLEX

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