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Structure paper

TitleDistortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 18924-18933, Year 2015
Publish dateSep 8, 2014 (structure data deposition date)
AuthorsMotozono, C. / Pearson, J.A. / De Leenheer, E. / Rizkallah, P.J. / Beck, K. / Trimby, A. / Sewell, A.K. / Wong, F.S. / Cole, D.K.
External linksJ. Biol. Chem. / PubMed:26085090
MethodsX-ray diffraction
Resolution1.88 - 2.313 Å
Structure data

PDB-4wdi:
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Method: X-RAY DIFFRACTION / Resolution: 2.313 Å

PDB-4z76:
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-4z78:
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Method: X-RAY DIFFRACTION / Resolution: 2.304 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin / H-2Kd / Type 1 Diabetes

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