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Structure paper

TitleStructural basis for mutation-induced destabilization of profilin 1 in ALS.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page 7984-7989, Year 2015
Publish dateNov 24, 2014 (structure data deposition date)
AuthorsBoopathy, S. / Silvas, T.V. / Tischbein, M. / Jansen, S. / Shandilya, S.M. / Zitzewitz, J.A. / Landers, J.E. / Goode, B.L. / Schiffer, C.A. / Bosco, D.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:26056300
MethodsX-ray diffraction
Resolution2.16 - 2.23 Å
Structure data

PDB-4x1l:
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-4x1m:
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

PDB-4x25:
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / ALS / Human Profilin-1 M114T Mutant ALS

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