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TitleIdentification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Journal, issue, pagesMol. Pharmacol., Vol. 88, Page 316-325, Year 2015
Publish dateOct 31, 2014 (structure data deposition date)
AuthorsMorooka, S. / Hoshina, M. / Kii, I. / Okabe, T. / Kojima, H. / Inoue, N. / Okuno, Y. / Denawa, M. / Yoshida, S. / Fukuhara, J. ...Morooka, S. / Hoshina, M. / Kii, I. / Okabe, T. / Kojima, H. / Inoue, N. / Okuno, Y. / Denawa, M. / Yoshida, S. / Fukuhara, J. / Ninomiya, K. / Ikura, T. / Furuya, T. / Nagano, T. / Noda, K. / Ishida, S. / Hosoya, T. / Ito, N. / Yoshimura, N. / Hagiwara, M.
External linksMol. Pharmacol. / PubMed:25993998
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4wua:
Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-3UL:
N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / kinase-inhibitor complex / pre-mRNA splicing / ATP-binding / TRANSFERASE-TRANSFERASE INHIBITOR complex

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