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Structure paper

TitleCDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Journal, issue, pagesNat Commun, Vol. 6, Page 6769-6769, Year 2015
Publish dateFeb 13, 2015 (structure data deposition date)
AuthorsBrown, N.R. / Korolchuk, S. / Martin, M.P. / Stanley, W.A. / Moukhametzianov, R. / Noble, M.E. / Endicott, J.A.
External linksNat Commun / PubMed:25864384
MethodsX-ray diffraction
Resolution2.3 - 2.7 Å
Structure data

PDB-4y72:
Human CDK1/CyclinB1/CKS2 With Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4yc3:
CDK1/CyclinB1/CKS2 Apo
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4yc6:
CDK1/CKS1
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5hq0:
Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-LZ9:
{[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CDK1 / CyclinB1 / CKS2 / Inhibitor / CELL CYCLE / Cyclin B1 / Cyclin B / Cell-cycle / protein kinase

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