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TitleRibosome. The structure of the human mitochondrial ribosome.
Journal, issue, pagesScience, Vol. 348, Issue 6230, Page 95-98, Year 2015
Publish dateApr 3, 2015
AuthorsAlexey Amunts / Alan Brown / Jaan Toots / Sjors H W Scheres / V Ramakrishnan /
PubMed AbstractThe highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact ...The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. The head domain of the small subunit, particularly the messenger (mRNA) channel, is highly remodeled. Many intersubunit bridges are specific to the mitoribosome, which adopts conformations involving ratcheting or rolling of the small subunit that are distinct from those seen in bacteria or eukaryotes. An intrinsic guanosine triphosphatase mediates a contact between the head and central protuberance. The structure provides a reference for analysis of mutations that cause severe pathologies and for future drug design.
External linksScience / PubMed:25838379 / PubMed Central
MethodsEM (single particle)
Resolution3.27 - 4.7 Å
Structure data

2876

3j9m

EMDB-2876: The structure of the human mitochondrial ribosome (class 1).
PDB-3j9m: Structure of the human mitochondrial ribosome (class 1)
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-2877:
The structure of the human mitochondrial ribosome (class 2).
Method: EM (single particle) / Resolution: 4.1 Å

EMDB-2878:
The structure of the human mitochondrial ribosome (class 3)
Method: EM (single particle) / Resolution: 4.7 Å

EMDB-2879:
The structure of the human mitochondrial ribosome (large subunit, masked)
Method: EM (single particle) / Resolution: 3.27 Å

EMDB-2880:
The structure of the human mitochondrial ribosome (small subunit, masked)
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-2881:
The structure of the human mitochondrial ribosome (small subunit head masked)
Method: EM (single particle) / Resolution: 3.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM / Guanosine diphosphate

Source
  • homo sapiens (human)
KeywordsRIBOSOME / Mitochondria / translation

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