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Title | A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 23, Page 2247-2260, Year 2015 |
Publish date | Sep 9, 2014 (structure data deposition date) |
![]() | Kusakabe, K. / Ide, N. / Daigo, Y. / Itoh, T. / Yamamoto, T. / Kojima, E. / Mitsuoka, Y. / Tadano, G. / Tagashira, S. / Higashino, K. ...Kusakabe, K. / Ide, N. / Daigo, Y. / Itoh, T. / Yamamoto, T. / Kojima, E. / Mitsuoka, Y. / Tadano, G. / Tagashira, S. / Higashino, K. / Okano, Y. / Sato, Y. / Inoue, M. / Iguchi, M. / Kanazawa, T. / Ishioka, Y. / Dohi, K. / Kido, Y. / Sakamoto, S. / Ando, S. / Maeda, M. / Higaki, M. / Yoshizawa, H. / Murai, H. / Nakamura, Y. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.9 - 3.05 Å |
Structure data | ![]() PDB-3wyx: ![]() PDB-3wyy: |
Chemicals | ![]() ChemComp-IOD: ![]() ChemComp-O38: ![]() ChemComp-HOH: ![]() ChemComp-O17: |
Source |
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![]() | TRANSFERASE / KINASE / ATP Binding / SERINE/THREONINE-PROTEIN KINASE / INHIBITOR COMPLEX |