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TitleCrystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
Journal, issue, pagesBiochem. J., Vol. 468, Page 283-291, Year 2015
Publish dateDec 25, 2014 (structure data deposition date)
AuthorsLorenz, S. / Deng, P. / Hantschel, O. / Superti-Furga, G. / Kuriyan, J.
External linksBiochem. J. / PubMed:25779001
MethodsX-ray diffraction
Resolution2.891 Å
Structure data

PDB-4xey:
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
Method: X-RAY DIFFRACTION / Resolution: 2.891 Å

Chemicals

ChemComp-1N1:
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE / medication*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / tyrosine kinase / kinase domain / SH2 domain / dasatinib / TRANSFERASE-TRANSFERASE INHIBITOR complex

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