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-Structure paper
タイトル | Structural organization of the dynein-dynactin complex bound to microtubules. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 22, Issue 4, Page 345-347, Year 2015 |
掲載日 | 2015年3月9日 |
著者 | Saikat Chowdhury / Stephanie A Ketcham / Trina A Schroer / Gabriel C Lander / |
PubMed 要旨 | Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the ...Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible. |
リンク | Nat Struct Mol Biol / PubMed:25751425 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 6.5 - 24.0 Å |
構造データ | EMDB-6289: EMDB-6290: |
由来 |
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