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Structure paper

TitleAutoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
Journal, issue, pagesElife, Vol. 4, Year 2015
Publish dateJan 6, 2015 (structure data deposition date)
AuthorsWang, Q. / Vogan, E.M. / Nocka, L.M. / Rosen, C.E. / Zorn, J.A. / Harrison, S.C. / Kuriyan, J.
External linksElife / PubMed:25699547
MethodsX-ray diffraction
Resolution1.599 - 2.6 Å
Structure data

PDB-4xi2:
Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4y93:
Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk)
Method: X-RAY DIFFRACTION / Resolution: 1.695 Å

PDB-4y94:
Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4y95:
Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop
Method: X-RAY DIFFRACTION / Resolution: 1.599 Å

Chemicals

ChemComp-AU:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-746:
4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

Source
  • mus musculus (house mouse)
  • bos taurus (domestic cattle)
KeywordsTRANSFERASE / Kinase / Phosphorylation / Auto-inhibited / B-Cell development / X-linked agammaglobulinemia / PH-TH / Btk / tyrosine kinase / PH domain / inositol hexakisphosphate / kinase domain

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