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Structure paper

TitleStabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
Journal, issue, pagesJ. Mol. Biol., Vol. 427, Page 1389-1403, Year 2015
Publish dateJul 8, 2014 (structure data deposition date)
AuthorsZhao, B. / Gandhi, S. / Yuan, C. / Luo, Z. / Li, R. / Gardsvoll, H. / de Lorenzi, V. / Sidenius, N. / Huang, M. / Ploug, M.
External linksJ. Mol. Biol. / PubMed:25659907
MethodsX-ray diffraction
Resolution2.17 - 3 Å
Structure data

PDB-4qth:
Crystal structure of anti-uPAR Fab 8B12
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

PDB-4qti:
Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody / allosteric regulation / cell surface

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