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TitleThe Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 9500-9510, Year 2015
Publish dateSep 21, 2013 (structure data deposition date)
AuthorsBhattacharjee, A. / Reuter, S. / Trojnar, E. / Kolodziejczyk, R. / Seeberger, H. / Hyvarinen, S. / Uzonyi, B. / Szilagyi, A. / Prohaszka, Z. / Goldman, A. ...Bhattacharjee, A. / Reuter, S. / Trojnar, E. / Kolodziejczyk, R. / Seeberger, H. / Hyvarinen, S. / Uzonyi, B. / Szilagyi, A. / Prohaszka, Z. / Goldman, A. / Jozsi, M. / Jokiranta, T.S.
External linksJ. Biol. Chem. / PubMed:25659429
MethodsX-ray diffraction
Resolution2.897 Å
Structure data

PDB-4muc:
The 4th and 5th C-terminal domains of Factor H related protein 1
Method: X-RAY DIFFRACTION / Resolution: 2.897 Å

Chemicals

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Sushi domains / Complement Alternative Pathway / Factor H related proteins

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