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Structure paper

TitleStructural insights into mis-regulation of protein kinase A in human tumors.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page 1374-1379, Year 2015
Publish dateSep 2, 2014 (structure data deposition date)
AuthorsCheung, J. / Ginter, C. / Cassidy, M. / Franklin, M.C. / Rudolph, M.J. / Robine, N. / Darnell, R.B. / Hendrickson, W.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:25605907
MethodsX-ray diffraction
Resolution1.55 - 2.1 Å
Structure data

PDB-4wb5:
Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit)
Method: X-RAY DIFFRACTION / Resolution: 1.641 Å

PDB-4wb6:
Crystal structure of a L205R mutant of human cAMP-dependent protein kinase A (catalytic alpha subunit)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4wb7:
Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4wb8:
Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE inhibitor / catalysis / protein kinase / adenosine triphosphate / phosphorylation / TRANSFERASE-TRANSFERASE inhibitor complex / Cushing's syndrome / mutant / chaperone / chimera / fusion / fibrolamellar hepatocellular carinoma

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