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Structure paper

TitleCrystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
Journal, issue, pagesStructure, Vol. 23, Page 418-424, Year 2015
Publish dateAug 16, 2014 (structure data deposition date)
AuthorsHarshbarger, W. / Miller, C. / Diedrich, C. / Sacchettini, J.
External linksStructure / PubMed:25599644
MethodsX-ray diffraction
Resolution2.6 - 2.89 Å
Structure data

PDB-4r3o:
Human Constitutive 20S Proteasome
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4r67:
Human constitutive 20S proteasome in complex with carfilzomib
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-3BV:
N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide / medication, anticancer, inhibitor*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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