タイトル | Antibacterial drug leads: DNA and enzyme multitargeting. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 58, Page 1215-1227, Year 2015 |
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掲載日 | 2014年8月29日 (構造データの登録日) |
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著者 | Zhu, W. / Wang, Y. / Li, K. / Gao, J. / Huang, C.H. / Chen, C.C. / Ko, T.P. / Zhang, Y. / Guo, R.T. / Oldfield, E. |
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リンク | J. Med. Chem. / PubMed:25574764 |
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手法 | X線回折 |
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解像度 | 1.24 - 2.1 Å |
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構造データ | PDB-3wyi: Structure of S. aureus undecaprenyl diphosphate synthase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-3wyj: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4u82: Structure of S. aureus undecaprenyl diphosphate synthase in complex with FSPP and sulfate 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å PDB-4u8a: Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1503 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-4u8b: Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1358 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å PDB-4u8c: Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1409 手法: X-RAY DIFFRACTION / 解像度: 1.24 Å |
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化合物 | ChemComp-3EZ: N,N'-bis[3-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]biphenyl-4,4'-dicarboxamide / N,N′-ビス[3-(1,4,5,6-テトラヒドロピリミジン-2-イル)フェニル]-1,1′-ビフェニル-4,4′-ジ(以下略)
ChemComp-3F6: 2,2'-benzene-1,4-diylbis[6-(1,4,5,6-tetrahydropyrimidin-2-yl)-1H-indole] / 2,2′-(1,4-フェニレン)ビス[6-(1,4,5,6-テトラヒドロピリミジン-2-イル)-1H-インド-ル]
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由来 | ![](img/tx_bacteria.gif) ![](data/taxo/wicon/Staphylococcus_aureus_01.jpg) staphylococcus aureus (黄色ブドウ球菌)![](img/tx_bacteria.gif) ![](data/taxo/icon/Escherichia_coli_S.png) escherichia coli k-12 (大腸菌)- synthetic construct (人工物)
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キーワード | TRANSFERASE (転移酵素) / isopentenyl diphosphate binding (イソペンテニル二リン酸) / product inhibition / Alkyl and Aryl Transferases / Anti-Bacterial Agents (抗菌薬) / Benzoates / Biosynthetic Pathways / Cell Wall (細胞壁) / Diphosphonates / Drug Discovery (創薬) / High-Throughput Screening Assays / Methicillin / Microbial Sensitivity Tests / Pyrrolidinones / Staphylococcus aureus (黄色ブドウ球菌) / Terpenes / DNA/ANTIBIOTIC / Antibacterial Agents / Bisamidines / Minor Groove Binders / Models / Molecular (分子) / Nucleic Acid Conformation / Oligodeoxyribonucleotides (オリゴヌクレオチド) / DNA-ANTIBIOTIC complex |
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