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-Structure paper
Title | Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2. |
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Journal, issue, pages | J. Biol. Chem., Vol. 290, Page 3248-3268, Year 2015 |
Publish date | Aug 8, 2014 (structure data deposition date) |
Authors | Pallan, P.S. / Nagy, L.D. / Lei, L. / Gonzalez, E. / Kramlinger, V.M. / Azumaya, C.M. / Wawrzak, Z. / Waterman, M.R. / Guengerich, F.P. / Egli, M. |
External links | J. Biol. Chem. / PubMed:25533464 |
Methods | X-ray diffraction |
Resolution | 2.7 - 3.3 Å |
Structure data | PDB-4r1z: PDB-4r20: PDB-4r21: |
Chemicals | ChemComp-HEM: ChemComp-AER: ChemComp-HOH: ChemComp-HG: ChemComp-STR: |
Source |
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Keywords | OXIDOREDUCTASE / Cytochrome P450 17A1 / Abiraterone / 17 (alpha)-hydroxylation / 17alpha / 20-lyase / steroid biosynthesis / enzyme kinetics / zebrafish / P450 17A1 / 17(alpha)-hydroylation / lysase reaction / Cytochrome P450 17A2 / progesterone / P450 17A2 |