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TitleAntibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved.
Journal, issue, pagesImmunity, Vol. 41, Page 909-918, Year 2014
Publish dateMay 19, 2014 (structure data deposition date)
AuthorsWiehe, K. / Easterhoff, D. / Luo, K. / Nicely, N.I. / Bradley, T. / Jaeger, F.H. / Dennison, S.M. / Zhang, R. / Lloyd, K.E. / Stolarchuk, C. ...Wiehe, K. / Easterhoff, D. / Luo, K. / Nicely, N.I. / Bradley, T. / Jaeger, F.H. / Dennison, S.M. / Zhang, R. / Lloyd, K.E. / Stolarchuk, C. / Parks, R. / Sutherland, L.L. / Scearce, R.M. / Morris, L. / Kaewkungwal, J. / Nitayaphan, S. / Pitisuttithum, P. / Rerks-Ngarm, S. / Sinangil, F. / Phogat, S. / Michael, N.L. / Kim, J.H. / Kelsoe, G. / Montefiori, D.C. / Tomaras, G.D. / Bonsignori, M. / Santra, S. / Kepler, T.B. / Alam, S.M. / Moody, M.A. / Liao, H.X. / Haynes, B.F.
External linksImmunity / PubMed:25526306
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4qf1:
Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-CL:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / anti-HIV antibody / gp120

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