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TitleThe Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 70, Page 3212-, Year 2014
Publish dateAug 19, 2013 (structure data deposition date)
AuthorsKiema, T.-R. / Harijan, R.K. / Strozyk, M. / Fukao, T. / Alexson, S.E.H. / Wierenga, R.K.
External linksActa Crystallogr. ,Sect. D / PubMed:25478839
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4c2j:
Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4c2k:
Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-COA:
COENZYME A

ChemComp-HOH:
WATER

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / FATTY ACID METABOLISM / MITOCHONDRIAL BETA-OXIDATION / THIOLYTIC CLEAVAGE

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