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Structure paper

TitleDNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
Journal, issue, pagesScience, Vol. 346, Page 1127-1130, Year 2014
Publish dateOct 5, 2014 (structure data deposition date)
AuthorsWang, R. / Persky, N.S. / Yoo, B. / Ouerfelli, O. / Smogorzewska, A. / Elledge, S.J. / Pavletich, N.P.
External linksScience / PubMed:25430771
MethodsX-ray diffraction
Resolution2.8 - 3.3 Å
Structure data

PDB-4ri8:
FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4ri9:
FAN1 Nuclease bound to 5' phosphorylated p(dT)/3'(dT-dT-dT-dT-dT-dT-dT-dT) double flap DNA
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4ria:
FAN1 Nuclease bound to 5' phosphorylated nicked DNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4rib:
FAN1 Nuclease bound to 5' phosphorylated p(dT) single flap DNA
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-4ric:
FAN1 Nuclease bound to 5' hydroxyl (dT-dT) single flap DNA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4rid:
Human FAN1 nuclease
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-BA:
Unknown entry

Source
  • homo sapiens (human)
Keywordshydrolase/dna / nuclease / hydrolase-dna complex / HYDROLASE

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