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Structure paper

TitleStructural basis for inhibition of DNA replication by aphidicolin.
Journal, issue, pagesNucleic Acids Res., Vol. 42, Page 14013-14021, Year 2014
Publish dateApr 17, 2014 (structure data deposition date)
AuthorsBaranovskiy, A.G. / Babayeva, N.D. / Suwa, Y. / Gu, J. / Pavlov, Y.I. / Tahirov, T.H.
External linksNucleic Acids Res. / PubMed:25429975
MethodsX-ray diffraction
Resolution2.52 Å
Structure data

PDB-4q5v:
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

Chemicals

ChemComp-2ZE:
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthale / antibiotic, antivirus, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA/RNA / B-family DNA polymerase / DNA replication / TRANSFERASE-DNA-RNA complex

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