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Structure paper

TitleStructure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 17420-17425, Year 2014
Publish dateJun 24, 2014 (structure data deposition date)
AuthorsAgrawal, A.A. / McLaughlin, K.J. / Jenkins, J.L. / Kielkopf, C.L.
External linksProc. Natl. Acad. Sci. USA / PubMed:25422459
MethodsX-ray diffraction
Resolution1.918 - 2.087 Å
Structure data

PDB-4tu7:
Structure of U2AF65 D231V variant with BrU5 DNA
Method: X-RAY DIFFRACTION / Resolution: 2.087 Å

PDB-4tu8:
STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA
Method: X-RAY DIFFRACTION / Resolution: 1.918 Å

PDB-4tu9:
STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA
Method: X-RAY DIFFRACTION / Resolution: 1.992 Å

Chemicals

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CPQ:
N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE / detergent*YM

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsRNA binding Protein/DNA / pre-mRNA splicing factor / RNA Recognition Motif / RNA binding Protein-DNA complex / RNA SPLICING FACTOR / RNA BINDING PROTEIN

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