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Title | Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 10499-10511, Year 2014 |
Publish date | Oct 30, 2014 (structure data deposition date) |
Authors | Rew, Y. / Sun, D. / Yan, X. / Beck, H.P. / Canon, J. / Chen, A. / Duquette, J. / Eksterowicz, J. / Fox, B.M. / Fu, J. ...Rew, Y. / Sun, D. / Yan, X. / Beck, H.P. / Canon, J. / Chen, A. / Duquette, J. / Eksterowicz, J. / Fox, B.M. / Fu, J. / Gonzalez, A.Z. / Houze, J. / Huang, X. / Jiang, M. / Jin, L. / Li, Y. / Li, Z. / Ling, Y. / Lo, M.C. / Long, A.M. / McGee, L.R. / McIntosh, J. / Oliner, J.D. / Osgood, T. / Saiki, A.Y. / Shaffer, P. / Wang, Y.C. / Wortman, S. / Yakowec, P. / Ye, Q. / Yu, D. / Zhao, X. / Zhou, J. / Medina, J.C. / Olson, S.H. |
External links | J. Med. Chem. / PubMed:25384157 |
Methods | X-ray diffraction |
Resolution | 1.42 Å |
Structure data | PDB-4wt2: |
Chemicals | ChemComp-3UD: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | LIGASE/LIGASE INHIBITOR / P53 / PROTEIN-PROTEIN INTERACTION / LIGASE-LIGASE INHIBITOR complex |