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-Structure paper
Title | Design of gem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation. |
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Journal, issue, pages | Chemmedchem, Vol. 10, Page 107-115, Year 2015 |
Publish date | Aug 5, 2014 (structure data deposition date) |
![]() | Ghosh, A.K. / Yashchuk, S. / Mizuno, A. / Chakraborty, N. / Agniswamy, J. / Wang, Y.F. / Aoki, M. / Gomez, P.M. / Amano, M. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.3 Å |
Structure data | ![]() PDB-4u8w: |
Chemicals | ![]() ChemComp-G10: ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE Inhibitor / HIV-1 protease inhibitor / multidrug-resistant HIV-1 strains / blood-brain-barrier / fluoro-bis-THF / HYDROLASE-HYDROLASE Inhibitor complex |