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-Structure paper
| Title | Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. |
|---|---|
| Journal, issue, pages | Nat. Cell Biol., Vol. 16, Page 1069-1079, Year 2014 |
| Publish date | May 4, 2014 (structure data deposition date) |
 Authors | Dowdle, W.E. / Nyfeler, B. / Nagel, J. / Elling, R.A. / Liu, S. / Triantafellow, E. / Menon, S. / Wang, Z. / Honda, A. / Pardee, G. ...Dowdle, W.E. / Nyfeler, B. / Nagel, J. / Elling, R.A. / Liu, S. / Triantafellow, E. / Menon, S. / Wang, Z. / Honda, A. / Pardee, G. / Cantwell, J. / Luu, C. / Cornella-Taracido, I. / Harrington, E. / Fekkes, P. / Lei, H. / Fang, Q. / Digan, M.E. / Burdick, D. / Powers, A.F. / Helliwell, S.B. / D'Aquin, S. / Bastien, J. / Wang, H. / Wiederschain, D. / Kuerth, J. / Bergman, P. / Schwalb, D. / Thomas, J. / Ugwonali, S. / Harbinski, F. / Tallarico, J. / Wilson, C.J. / Myer, V.E. / Porter, J.A. / Bussiere, D.E. / Finan, P.M. / Labow, M.A. / Mao, X. / Hamann, L.G. / Manning, B.D. / Valdez, R.A. / Nicholson, T. / Schirle, M. / Knapp, M.S. / Keaney, E.P. / Murphy, L.O. |
 External links | Nat. Cell Biol. / PubMed:25327288 |
| Methods | X-ray diffraction |
| Resolution | 2.8 Å |
| Structure data |  PDB-4ph4: |
| Chemicals |  ChemComp-GOL:  ChemComp-2UG:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / VPS34 / autophagy / class III / phosphatidylinositol-3-kinase / PIK3C3 / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)