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-Structure paper
| Title | Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. |
|---|---|
| Journal, issue, pages | ACS MED. CHEM. LETT., Vol. 5, Page 1088-1093, Year 2014 |
| Publish date | Jul 16, 2014 (structure data deposition date) |
 Authors | Tao, Z.F. / Hasvold, L. / Wang, L. / Wang, X. / Petros, A.M. / Park, C.H. / Boghaert, E.R. / Catron, N.D. / Chen, J. / Colman, P.M. ...Tao, Z.F. / Hasvold, L. / Wang, L. / Wang, X. / Petros, A.M. / Park, C.H. / Boghaert, E.R. / Catron, N.D. / Chen, J. / Colman, P.M. / Czabotar, P.E. / Deshayes, K. / Fairbrother, W.J. / Flygare, J.A. / Hymowitz, S.G. / Jin, S. / Judge, R.A. / Koehler, M.F. / Kovar, P.J. / Lessene, G. / Mitten, M.J. / Ndubaku, C.O. / Nimmer, P. / Purkey, H.E. / Oleksijew, A. / Phillips, D.C. / Sleebs, B.E. / Smith, B.J. / Smith, M.L. / Tahir, S.K. / Watson, K.G. / Xiao, Y. / Xue, J. / Zhang, H. / Zobel, K. / Rosenberg, S.H. / Tse, C. / Leverson, J.D. / Elmore, S.W. / Souers, A.J. |
 External links | ACS MED. CHEM. LETT. / PubMed:25313317 |
| Methods | X-ray diffraction |
| Resolution | 2.1 Å |
| Structure data |  PDB-4qvx: |
| Chemicals |  ChemComp-3CQ:  ChemComp-HOH: |
| Source |
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 Keywords | APOPTOSIS/INHIBITOR / 8 alpha helices / Anti-apoptotic / Pro-apoptotic / APOPTOSIS-INHIBITOR complex |
homo sapiens (human)