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TitleStructure and immune recognition of trimeric pre-fusion HIV-1 Env.
Journal, issue, pagesNature, Vol. 514, Page 455-461, Year 2014
Publish dateJun 27, 2014 (structure data deposition date)
AuthorsPancera, M. / Zhou, T. / Druz, A. / Georgiev, I.S. / Soto, C. / Gorman, J. / Huang, J. / Acharya, P. / Chuang, G.Y. / Ofek, G. ...Pancera, M. / Zhou, T. / Druz, A. / Georgiev, I.S. / Soto, C. / Gorman, J. / Huang, J. / Acharya, P. / Chuang, G.Y. / Ofek, G. / Stewart-Jones, G.B. / Stuckey, J. / Bailer, R.T. / Joyce, M.G. / Louder, M.K. / Tumba, N. / Yang, Y. / Zhang, B. / Cohen, M.S. / Haynes, B.F. / Mascola, J.R. / Morris, L. / Munro, J.B. / Blanchard, S.C. / Mothes, W. / Connors, M. / Kwong, P.D.
External linksNature / PubMed:25296255
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-4tvp:
Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 ENVELOPE Trimer / gp120 / gp41 / MEMBRANE FUSION / VIRAL ENTRY / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / TYPE-1 MEMBRANE FUSION GLYCOPROTEIN

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