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Structure paper

TitleThe Structure of a Tetrameric [Alpha]-Carbonic Anhydrase from Thermovibrio Ammonificans Reveals a Core Formed Around Intermolecular Disulfides that Contribute to its Thermostability
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 70, Page 2607-, Year 2014
Publish dateAug 27, 2013 (structure data deposition date)
AuthorsJames, P. / Isupov, M.N. / Sayer, C. / Saneei, V. / Berg, S. / Lioliou, M. / Kotlar, H. / Littlechild, J.
External linksActa Crystallogr. ,Sect. D / PubMed:25286845
MethodsX-ray diffraction
Resolution1.55 - 1.85 Å
Structure data

PDB-4c3t:
The Carbonic anhydrase from Thermovibrio ammonificans reveals an interesting intermolecular disulfide contributing to increasing thermal stability of this enzyme
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-4coq:
The complex of alpha-Carbonic anhydrase from Thermovibrio ammonificans with inhibitor sulfanilamide.
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-4uov:
The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides, which contribute to its thermostability.
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SAN:
SULFANILAMIDE / antibiotic*YM

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-AZM:
5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE / medication*YM

ChemComp-PE3:
3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-PG5:
1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE

Source
  • thermovibrio ammonificans (bacteria)
KeywordsLYASE / THERMOPHILIC / ACETAZOLAMIDE / CARBON DIOXIDE CAPTURE / THERMAL STABILITY / CARBONIC ANHYDRASE / THERMAL STABILITY.

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