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-Structure paper
Title | Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site. |
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Journal, issue, pages | Protein Eng. Des. Sel., Vol. 27, Page 391-397, Year 2014 |
Publish date | Feb 26, 2014 (structure data deposition date) |
![]() | Fanning, S.W. / Walter, R. / Horn, J.R. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.5 - 1.75 Å |
Structure data | ![]() PDB-4pou: ![]() PDB-4poy: ![]() PDB-4ppt: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-NI: ![]() ChemComp-SO4: |
Source |
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![]() | Hydrolase/Immune System / Hydrolase-Immune System complex / IMMUNE SYSTEM / Single domain antibody / VHH / Metalloregulation / Bispecific / Dual-Function / Protein Engineering / Affinity Control / Protein-Switch / Antibody Engineering / Nickel Binding Protein / Protein-Metal Coordination Geometry / Loop Dynamics / Protein Flexibility / Conformational Dynamics / Binding Thermodynamics / Antibody-metal Complex |