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Structure paper

TitleStructural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 70, Page 1965-1976, Year 2014
Publish dateJun 18, 2013 (structure data deposition date)
AuthorsLori, C. / Pasquo, A. / Montanari, R. / Capelli, D. / Consalvi, V. / Chiaraluce, R. / Cervoni, L. / Loiodice, F. / Laghezza, A. / Aschi, M. ...Lori, C. / Pasquo, A. / Montanari, R. / Capelli, D. / Consalvi, V. / Chiaraluce, R. / Cervoni, L. / Loiodice, F. / Laghezza, A. / Aschi, M. / Giorgi, A. / Pochetti, G.
External linksActa Crystallogr. ,Sect. D / PubMed:25004973
MethodsX-ray diffraction
Resolution2.28 - 2.6 Å
Structure data

PDB-4l96:
Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space group I222)
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

PDB-4l98:
Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-4o8f:
Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-LRG:
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid

ChemComp-HOH:
WATER

ChemComp-BRL:
2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/TRANSCRIPTION inhibitor / transcription factor / RXRalpha / TRANSCRIPTION-TRANSCRIPTION inhibitor complex / BUNDLE OF ALPHA-HELICES / SMALL FOUR-STRANDED BETA-SHEET

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