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Structure paper

TitleIP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.
Journal, issue, pagesNat Commun, Vol. 5, Page 4178-4178, Year 2014
Publish dateDec 18, 2013 (structure data deposition date)
AuthorsWang, H. / DeRose, E.F. / London, R.E. / Shears, S.B.
External linksNat Commun / PubMed:24956979
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-4o4b:
Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA as a fusion protein with maltose binding protein
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4o4c:
Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4o4d:
Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA in complexed with ATP and Ins(1,4,5)P3
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4o4e:
Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA in complexed with ATP and Ins(1,3,4,5,6)P5
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4o4f:
Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA in complexed with ATP and InsP6
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER / Water

ChemComp-MG:
Unknown entry

ChemComp-I3P:
D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE / Inositol trisphosphate

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

ChemComp-PO4:
PHOSPHATE ION / Phosphate

ChemComp-ACT:
ACETATE ION / Acetate

ChemComp-5MY:
MYO-INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE / Phytic acid

Source
  • escherichia coli (E. coli)
  • entamoeba histolytica (eukaryote)
KeywordsTRANSPORT PROTEIN/Transferase / PDKG kinase / TRANSPORT PROTEIN-Transferase complex / TRANSFERASE / Inositol Phosphate / PDGK Kinase

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