タイトル | Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. |
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ジャーナル・号・ページ | ACS Med Chem Lett, Vol. 4, Page 660-665, Year 2013 |
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掲載日 | 2013年2月12日 (構造データの登録日) |
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著者 | Fry, D.C. / Wartchow, C. / Graves, B. / Janson, C. / Lukacs, C. / Kammlott, U. / Belunis, C. / Palme, S. / Klein, C. / Vu, B. |
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リンク | ACS Med Chem Lett / PubMed:24900726 |
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手法 | X線回折 |
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解像度 | 1.2 - 1.63 Å |
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構造データ | PDB-4j74: The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-4j7d: The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-4j7e: The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å |
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化合物 | ChemComp-I18: (4S,5R)-4,5-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-1H-imidazole
ChemComp-I31: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole
ChemComp-I29: [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone
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由来 | xenopus laevis (アフリカツメガエル)
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キーワード | LIGASE/ANTAGONIST / MDM2 / IMIDAZOLINE / LIGASE-ANTAGONIST COMPLEX / E3 UBIQUITIN LIGASE / P53 / NUCLEUS / PROTEIN-PROTEIN INTERACTION |
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