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-Structure paper
Title | Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 4, Page 660-665, Year 2013 |
Publish date | Feb 12, 2013 (structure data deposition date) |
Authors | Fry, D.C. / Wartchow, C. / Graves, B. / Janson, C. / Lukacs, C. / Kammlott, U. / Belunis, C. / Palme, S. / Klein, C. / Vu, B. |
External links | ACS Med Chem Lett / PubMed:24900726 |
Methods | X-ray diffraction |
Resolution | 1.2 - 1.63 Å |
Structure data | PDB-4j74: PDB-4j7d: PDB-4j7e: |
Chemicals | ChemComp-I18: ChemComp-SO4: ChemComp-HOH: ChemComp-I31: ChemComp-I29: |
Source |
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Keywords | LIGASE/ANTAGONIST / MDM2 / IMIDAZOLINE / LIGASE-ANTAGONIST COMPLEX / E3 UBIQUITIN LIGASE / P53 / NUCLEUS / PROTEIN-PROTEIN INTERACTION |