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TitleInhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania Infantum Proliferation
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 2, Page 230-, Year 2011
Publish dateFeb 3, 2010 (structure data deposition date)
AuthorsBaiocco, P. / Colotti, G. / Ilari, A.
External linksAcs Med. Chem. Lett. / PubMed:24900299
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-2x50:
Crystal structure of Trypanothione reductase from Leishmania infantum in complex with NADPH and silver
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-AG:
SILVER ION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • leishmania infantum (eukaryote)
KeywordsOXIDOREDUCTASE / FAD / FLAVOPROTEIN / LEISHMANIASIS / OXIDATIVE METABOLISM / REDOX-ACTIVE CENTER

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