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-Structure paper
Title | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 111, Page 8895-8900, Year 2014 |
Publish date | Jun 24, 2013 (structure data deposition date) |
![]() | Hunter, J.C. / Gurbani, D. / Ficarro, S.B. / Carrasco, M.A. / Lim, S.M. / Choi, H.G. / Xie, T. / Marto, J.A. / Chen, Z. / Gray, N.S. / Westover, K.D. |
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Methods | X-ray diffraction |
Resolution | 1.15 - 1.89 Å |
Structure data | ![]() PDB-4ldj: ![]() PDB-4nmm: ![]() PDB-4obe: |
Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-HOH: ![]() ChemComp-Y9Z: |
Source |
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![]() | HYDROLASE / Small GTPase / GDP bound / oncogenic mutation / HYDROLASE/HYDROLASE INHIBITOR / covalent inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex / signal transduction / GDP binding / GTP binding |