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TitleMolecular Mechanism of Aurora a Kinase Autophosphorylation and its Allosteric Activation by Tpx2.
Journal, issue, pagesElife, Vol. 3, Page 02667-, Year 2014
Publish dateAug 26, 2013 (structure data deposition date)
AuthorsZorba, A. / Buosi, V. / Kutter, S. / Kern, N. / Pontiggia, F. / Cho, Y.J. / Kern, D.
External linksElife / PubMed:24867643
MethodsX-ray diffraction
Resolution2.69 - 2.79 Å
Structure data

PDB-4c3p:
Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-4c3r:
Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ACTIVATION / ALLOSTERY / CELL CYCLE / CANCER / AURORA A

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