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Structure paper

TitleAn allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Journal, issue, pagesNat. Chem. Biol., Vol. 10, Page 567-573, Year 2014
Publish dateDec 18, 2013 (structure data deposition date)
AuthorsLandgraf, K.E. / Steffek, M. / Quan, C. / Tom, J. / Yu, C. / Santell, L. / Maun, H.R. / Eigenbrot, C. / Lazarus, R.A.
External linksNat. Chem. Biol. / PubMed:24859116
MethodsX-ray diffraction
Resolution2.99 - 3.04 Å
Structure data

PDB-4o3t:
Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP.14
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

PDB-4o3u:
Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3
Method: X-RAY DIFFRACTION / Resolution: 3.04 Å

Chemicals

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
  • synthetic (others)
Keywordstransferase/growth factor / trypsin homology / receptor activation / transferase-growth factor complex / trypsin homoloy

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