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TitleStructural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.
Journal, issue, pagesElife, Vol. 3, Page e02362-e02362, Year 2014
Publish dateMar 25, 2014 (structure data deposition date)
AuthorsJia, X. / Weber, E. / Tokarev, A. / Lewinski, M. / Rizk, M. / Suarez, M. / Guatelli, J. / Xiong, Y.
External linksElife / PubMed:24843023
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-4p6z:
Crystal structure of the human BST2 cytoplasmic domain and the HIV-1 Vpu cytoplasmic domain bound to the clathrin adaptor protein complex 1 (AP1) core
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
  • human immunodeficiency virus type 1 group m subtype b
KeywordsPROTEIN TRANSPORT / BST2 / tetherin / Vpu / HIV / clathrin / AP1 / antiviral / restriction factor / antagonism

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