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TitleAtomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 13801-13809, Year 2014
Publish dateDec 13, 2013 (structure data deposition date)
AuthorsMahalingam, B. / Van Agthoven, J.F. / Xiong, J.P. / Alonso, J.L. / Adair, B.D. / Rui, X. / Anand, S. / Mehrbod, M. / Mofrad, M.R. / Burger, C. ...Mahalingam, B. / Van Agthoven, J.F. / Xiong, J.P. / Alonso, J.L. / Adair, B.D. / Rui, X. / Anand, S. / Mehrbod, M. / Mofrad, M.R. / Burger, C. / Goodman, S.L. / Arnaout, M.A.
External linksJ. Biol. Chem. / PubMed:24692540
MethodsX-ray diffraction
Resolution3.605 Å
Structure data

PDB-4o02:
AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.
Method: X-RAY DIFFRACTION / Resolution: 3.605 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MN:
Unknown entry

ChemComp-NO3:
NITRATE ION

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING

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